产品货号：
Z12277
中文名称：
CARD10抗体
英文名称：
Anti-CARD10 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CARD10 Antibody |
| 指标别名 | BIMP1;CARMA3;Caspase recruitment domain-containing protein 10;CARD-containing MAGUK protein 3;Carma 3 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IHC |
| 基因名称 | CARD10 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | CARMA3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3.The immunogen is located within the first 50 amino acids of CARMA3. |
| 计算分子量 | 116kDa |
| 成分 | CARMA3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | CARMA3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules.CARMA1,CARMA2,and CARMA3 share high degrees of sequence and functional homology,but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types.As with CARMA1,the CARD domain of CARMA3 has been shown to specifically interact with BCL10,a protein known to function as a positive regulator of cell apoptosis and NF-百B activation.When expressed in cells,this protein binds to BCL10 and activates NF-百B Recent experiments have shown that CARMA3 is required for EGF-induced NF-百B activation and contributes to tumor growth in vivo,suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors. |
| Uniprot ID | Q9BWT7 |
| 基因名全称 | Caspase recruitment domain family,member 10 |
| 蛋白名全称 | Caspase recruitment domain family,member 10 |
| 推荐稀释比 | CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5μg/mL.Antibody validated:Immunohistochemistry in human samples.All other applications and species not yet tested. |
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